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This product utilizes the lipid nanoparticle (LNP) technology platform for simple and efficient delivery of the Luciferase mRNA to a variety of mammalian cells, including cell cultures which may typically be prone to difficulties in expressing desired proteins. The lipid nanoparticles used are formulated with, SM-102, DSPC, cholesterol, and DMG-PEG2000 at optimal molar concentration for a high rate of encapsulation and efficient mRNA delivery. Luciferase (Luc) is a light producing ezyme originally found in fireflies, Renilla, and other insects. In the presence of ATP, oxygen, and substrate (typically luciferin), these ezymatically active Luciferase proteins will catalyze the oxidation of the substrate which will result in the emmision of photons. The addition of this protein to mRNA will allow for easier identification and visualization of desired transfection results. This ability has rendered the Luciferase protein a candid vice for mRNA delivery. mRNA encapsulated in lipid nanoparticle, primarily in PBS (-ca, -mg). Dilute levels of: sodium acetate, ethanol, free mRNA & free lipids.
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